SNRIs
Serotonin plus norepinephrine
Depression and anxiety; duloxetine is also used for nerve pain and fibromyalgia.
Blocks the reuptake of both serotonin and norepinephrine.
The 3 snris in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Duloxetine | Cymbalta | depression, neuropathy, fibro |
| Venlafaxine | Effexor | depression, anxiety |
| Desvenlafaxine | Pristiq | depression |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleDuloxetine's pain indications set it apart from the SSRIs.
- check_circleVenlafaxine and desvenlafaxine are closely related — one is the active form of the other.
- check_circleBlood pressure can rise, especially at higher doses.
- check_circleDuloxetine capsules are delayed-release and must not be crushed or chewed.
Stopping venlafaxine abruptly is well known for causing discontinuation symptoms. Taper it.
SNRIs carry the same antidepressant class warning as SSRIs.
Drill snris the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What drugs are in the snris class? add
Duloxetine, Venlafaxine, Desvenlafaxine. All are in the PTCB Top 200.
What are snris used for? add
Depression and anxiety; duloxetine is also used for nerve pain and fibromyalgia.
How do snris work? add
Blocks the reuptake of both serotonin and norepinephrine.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.