PTCE Top 200 · #31

Duloxetine

Cymbalta

Duloxetine is the generic name for the brand-name drug Cymbalta. It is a snri antidepressant used to treat depression, neuropathy, fibro. On the PTCE Top 200 drug list, Duloxetine ranks #31 and is one of the most frequently tested cns/psych medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.

Generic nameDuloxetine
Brand name(s)Cymbalta
Drug classSNRI antidepressant
Class groupCNS/Psych
Common usedepression, neuropathy, fibro
DEA scheduleUnscheduled
AvailabilityPrescription only (Rx)

What is Duloxetine used for?

SNRI for major depressive disorder; also used for generalized anxiety disorder and certain chronic pain conditions (indication varies by product).

What drug class is Duloxetine?

Duloxetine is a SNRI antidepressant in the CNS/Psych group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.

Common side effects of Duloxetine

Major interactions

Is Duloxetine a controlled substance?

No. Duloxetine is not a federally controlled substance (it is unscheduled by the DEA).

warning Boxed warning

BOXED WARNING: Antidepressants can increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults—monitor closely.

How to remember Duloxetine (PTCE mnemonic)

CYMbalta calms 'C' symptoms — DULOX-etine is the DUAL SNRI for mood + neuropathy/fibro pain. Watch BP, suicidality (boxed), withdrawal.
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PTCE exam tip

Duloxetine is an SNRI — used for depression AND nerve pain / fibromyalgia. Like SSRIs, it carries serotonin-syndrome risk in combinations.

Duloxetine FAQ

What is the brand name for Duloxetine?

The brand name for Duloxetine is Cymbalta.

What is Duloxetine used for?

Duloxetine is used to treat depression, neuropathy, fibro. SNRI for major depressive disorder; also used for generalized anxiety disorder and certain chronic pain conditions (indication varies by product).

What drug class is Duloxetine?

Duloxetine is a SNRI antidepressant (CNS/Psych group).

Is Duloxetine a controlled substance?

No. Duloxetine is not a federally controlled substance (it is unscheduled by the DEA).

Related drugs in the CNS/Psych group

Drill Duloxetine the way the PTCE asks it

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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).