Other cholesterol agents
When a statin isn't enough
High cholesterol or high triglycerides — added to a statin, or used when a statin isn't tolerated.
Each works at a different point: blocking absorption in the gut, clearing triglycerides, or helping the liver take up more LDL.
The 3 other cholesterol agents in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Ezetimibe | Zetia | high cholesterol (add-on) |
| Fenofibrate | Tricor | high triglycerides |
| Evolocumab | Repatha | high cholesterol (familial) |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleEzetimibe blocks cholesterol absorption in the small intestine.
- check_circleFenofibrate mainly targets triglycerides rather than LDL.
- check_circleEvolocumab is an injectable PCSK9 inhibitor, refrigerated until use.
- check_circleEzetimibe is frequently dispensed alongside a statin.
Combining a fibrate with a statin raises the risk of muscle injury — muscle symptoms in that pairing need reporting.
These are add-ons. The statin remains the foundation of cholesterol therapy.
Drill other cholesterol agents the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What drugs are in the other cholesterol agents class? add
Ezetimibe, Fenofibrate, Evolocumab. All are in the PTCB Top 200.
What are other cholesterol agents used for? add
High cholesterol or high triglycerides — added to a statin, or used when a statin isn't tolerated.
How do other cholesterol agents work? add
Each works at a different point: blocking absorption in the gut, clearing triglycerides, or helping the liver take up more LDL.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.