Other antidepressants
The ones that break the pattern
Depression when an SSRI or SNRI isn't the right fit — plus smoking cessation, insomnia and appetite support.
Each acts on a different mix of brain chemicals rather than serotonin reuptake alone.
The 5 other antidepressants in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Bupropion | Wellbutrin | depression, smoking cessation |
| Trazodone | Desyrel | depression, insomnia |
| Amitriptyline | Elavil | depression, nerve pain |
| Mirtazapine | Remeron | depression (sleep/appetite gain) |
| Doxepin | Silenor | insomnia (sleep maintenance) |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleBupropion is also marketed for smoking cessation, so a patient can end up on two products with the same ingredient.
- check_circleTrazodone is very often prescribed at low doses for sleep.
- check_circleMirtazapine tends to increase appetite and cause drowsiness.
- check_circleThe tricyclics — amitriptyline, doxepin — are older and have more anticholinergic effects.
Bupropion lowers the seizure threshold and is avoided in patients with a seizure or eating-disorder history.
Watch for duplicate therapy: bupropion under two different brand names is a classic order-entry catch.
Drill other antidepressants the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What drugs are in the other antidepressants class? add
Bupropion, Trazodone, Amitriptyline, Mirtazapine, Doxepin. All are in the PTCB Top 200.
What are other antidepressants used for? add
Depression when an SSRI or SNRI isn't the right fit — plus smoking cessation, insomnia and appetite support.
How do other antidepressants work? add
Each acts on a different mix of brain chemicals rather than serotonin reuptake alone.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.