What is the brand name for Sacubitril / Valsartan?
The brand name for Sacubitril / Valsartan is Entresto.
PTCE Top 200 · #199
Sacubitril / Valsartan
Entresto
Sacubitril / Valsartan is the generic name for the brand-name drug Entresto. It is an arni (neprilysin inhibitor + arb) used to treat heart failure (HFrEF). On the PTCE Top 200 drug list, Sacubitril / Valsartan ranks #199 and is one of the most frequently tested cardiovascular medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Sacubitril / Valsartan |
|---|---|
| Brand name(s) | Entresto |
| Drug class | ARNI (neprilysin inhibitor + ARB) |
| Class group | Cardiovascular |
| Common use | heart failure (HFrEF) |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Sacubitril / Valsartan used for?
Treatment of chronic heart failure with reduced ejection fraction (HFrEF) to reduce risk of cardiovascular death and hospitalization (product-specific).
What drug class is Sacubitril / Valsartan?
Sacubitril / Valsartan is an ARNI (neprilysin inhibitor + ARB) in the Cardiovascular group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Sacubitril / Valsartan
- arrow_rightLow blood pressure (hypotension)
- arrow_rightHyperkalemia
- arrow_rightKidney function changes
- arrow_rightCough
- arrow_rightDizziness
Major interactions
- arrow_rightACE inhibitors (contraindicated; requires 36-hour washout due to angioedema risk)
- arrow_rightAliskiren (contraindicated in diabetes; increased renal impairment/hyperkalemia risk)
- arrow_rightPotassium supplements/salt substitutes and potassium-sparing diuretics increase hyperkalemia risk
- arrow_rightNSAIDs may worsen renal function and reduce effect
- arrow_rightLithium levels may increase (toxicity risk)
Is Sacubitril / Valsartan a controlled substance?
No. Sacubitril / Valsartan is not a federally controlled substance (it is unscheduled by the DEA).
warning Boxed warning
Fetal toxicity: discontinue as soon as pregnancy is detected (ARB component).
How to remember Sacubitril / Valsartan (PTCE mnemonic)
ENTREST-o lets the heart REST — ARNI: sacubitril (neprilysin inhibitor) + valsartan (ARB). HFrEF gold-standard; NO ACE overlap (36hr washout → angioedema); NO pregnancy; ↑K+, hypotension.
lightbulb
PTCE exam tip
Entresto's rule: NEVER with an ACE inhibitor — a 36-hour washout is required (angioedema risk). Sacubitril + valsartan is the ARNI for reduced-ejection-fraction heart failure.
Sacubitril / Valsartan FAQ
What is Sacubitril / Valsartan used for?
Sacubitril / Valsartan is used to treat heart failure (HFrEF). Treatment of chronic heart failure with reduced ejection fraction (HFrEF) to reduce risk of cardiovascular death and hospitalization (product-specific).
What drug class is Sacubitril / Valsartan?
Sacubitril / Valsartan is an ARNI (neprilysin inhibitor + ARB) (Cardiovascular group).
Is Sacubitril / Valsartan a controlled substance?
No. Sacubitril / Valsartan is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Cardiovascular group
Drill Sacubitril / Valsartan the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).