What is the brand name for Sacubitril / Valsartan?
The brand name for Sacubitril / Valsartan is Entresto.
PTCB TOP 200 · #199
Sacubitril / Valsartan
Entresto
Sacubitril / Valsartan is the generic name for the brand-name drug Entresto. It is an arni (neprilysin inhibitor + arb) used to treat heart failure (HFrEF). On the PTCE Top 200 drug list, Sacubitril / Valsartan ranks #199 and is one of the most frequently tested cardiovascular medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Sacubitril / Valsartan |
|---|---|
| Brand name(s) | Entresto |
| Drug class | ARNI (neprilysin inhibitor + ARB) |
| Class group | Cardiovascular |
| Common use | heart failure (HFrEF) |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Sacubitril / Valsartan used for?
Treatment of chronic heart failure with reduced ejection fraction (HFrEF) to reduce risk of cardiovascular death and hospitalization (product-specific).
What drug class is Sacubitril / Valsartan?
Sacubitril / Valsartan is an ARNI (neprilysin inhibitor + ARB) in the Cardiovascular group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Sacubitril / Valsartan
- arrow_rightLow blood pressure (hypotension)
- arrow_rightHyperkalemia
- arrow_rightKidney function changes
- arrow_rightCough
- arrow_rightDizziness
Major interactions
- arrow_rightACE inhibitors (contraindicated; requires 36-hour washout due to angioedema risk)
- arrow_rightAliskiren (contraindicated in diabetes; increased renal impairment/hyperkalemia risk)
- arrow_rightPotassium supplements/salt substitutes and potassium-sparing diuretics increase hyperkalemia risk
- arrow_rightNSAIDs may worsen renal function and reduce effect
- arrow_rightLithium levels may increase (toxicity risk)
Is Sacubitril / Valsartan a controlled substance?
No. Sacubitril / Valsartan is not a federally controlled substance (it is unscheduled by the DEA).
warning Boxed warning
Fetal toxicity: discontinue as soon as pregnancy is detected (ARB component).
How to remember Sacubitril / Valsartan (PTCE mnemonic)
ENTREST-o lets the heart REST — ARNI: sacubitril (neprilysin inhibitor) + valsartan (ARB). HFrEF gold-standard; NO ACE overlap (36hr washout → angioedema); NO pregnancy; ↑K+, hypotension.
lightbulb
PTCE exam tip
Entresto's rule: NEVER with an ACE inhibitor — a 36-hour washout is required (angioedema risk). Sacubitril + valsartan is the ARNI for reduced-ejection-fraction heart failure.
Sacubitril / Valsartan FAQ
What is Sacubitril / Valsartan used for?
Sacubitril / Valsartan is used to treat heart failure (HFrEF). Treatment of chronic heart failure with reduced ejection fraction (HFrEF) to reduce risk of cardiovascular death and hospitalization (product-specific).
What drug class is Sacubitril / Valsartan?
Sacubitril / Valsartan is an ARNI (neprilysin inhibitor + ARB) (Cardiovascular group).
Is Sacubitril / Valsartan a controlled substance?
No. Sacubitril / Valsartan is not a federally controlled substance (it is unscheduled by the DEA).
Study guides that cover Sacubitril / Valsartan
Free, in-depth guides to the patterns behind this drug — no app needed.
Drug suffix cheat sheetthe suffix that gives away this drug's class
How to memorize the Top 200 drugsa method for locking in brand↔generic pairs
Pharmacy math cheat sheetthe five calculation types the PTCE asks
What changed on the 2026 PTCB examthe new domain weights for 2026See all PTCE study guides or browse the full Top 200 drug list.
Drill Sacubitril / Valsartan the way the PTCE asks it
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