What is the brand name for Ondansetron?
The brand name for Ondansetron is Zofran.
PTCE Top 200 · #53
Ondansetron
Zofran
Ondansetron is the generic name for the brand-name drug Zofran. It is an antiemetic (5-ht3 antagonist) used to treat nausea, vomiting. On the PTCE Top 200 drug list, Ondansetron ranks #53 and is one of the most frequently tested gastrointestinal medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Ondansetron |
|---|---|
| Brand name(s) | Zofran |
| Drug class | Antiemetic (5-HT3 antagonist) |
| Class group | Gastrointestinal |
| Common use | nausea, vomiting |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Ondansetron used for?
• Prevention of nausea and vomiting associated with chemotherapy and radiation therapy. • Prevention/treatment of postoperative nausea and vomiting.
What drug class is Ondansetron?
Ondansetron is an Antiemetic (5-HT3 antagonist) in the Gastrointestinal group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Ondansetron
- arrow_rightHeadache
- arrow_rightConstipation
- arrow_rightFatigue
- arrow_rightQT prolongation (risk)
Major interactions
- arrow_rightOther QT-prolonging drugs ↑ arrhythmia risk
- arrow_rightSerotonergic drugs may ↑ serotonin syndrome risk (rare)
- arrow_rightApomorphine (contraindicated) → profound hypotension/loss of consciousness
Is Ondansetron a controlled substance?
No. Ondansetron is not a federally controlled substance (it is unscheduled by the DEA).
How to remember Ondansetron (PTCE mnemonic)
ZO-fran aims for ZERO vomiting — onDANSETRON blocks 5-HT3. QT prolongation, headache, constipation; serotonin syndrome with SSRIs.
lightbulb
PTCE exam tip
The suffix -setron = a 5-HT3 antagonist for nausea. Ondansetron (Zofran) often comes as an ODT (orally disintegrating tablet).
Ondansetron FAQ
What is Ondansetron used for?
Ondansetron is used to treat nausea, vomiting. • Prevention of nausea and vomiting associated with chemotherapy and radiation therapy. • Prevention/treatment of postoperative nausea and vomiting.
What drug class is Ondansetron?
Ondansetron is an Antiemetic (5-HT3 antagonist) (Gastrointestinal group).
Is Ondansetron a controlled substance?
No. Ondansetron is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Gastrointestinal group
Drill Ondansetron the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).