What is the brand name for Ondansetron?
The brand name for Ondansetron is Zofran.
PTCB TOP 200 · #53
Ondansetron
Zofran
Ondansetron is the generic name for the brand-name drug Zofran. It is an antiemetic (5-ht3 antagonist) used to treat nausea, vomiting. On the PTCE Top 200 drug list, Ondansetron ranks #53 and is one of the most frequently tested gastrointestinal medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Ondansetron |
|---|---|
| Brand name(s) | Zofran |
| Drug class | Antiemetic (5-HT3 antagonist) |
| Class group | Gastrointestinal |
| Common use | nausea, vomiting |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Ondansetron used for?
• Prevention of nausea and vomiting associated with chemotherapy and radiation therapy. • Prevention/treatment of postoperative nausea and vomiting.
What drug class is Ondansetron?
Ondansetron is an Antiemetic (5-HT3 antagonist) in the Gastrointestinal group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Ondansetron
- arrow_rightHeadache
- arrow_rightConstipation
- arrow_rightFatigue
- arrow_rightQT prolongation (risk)
Major interactions
- arrow_rightOther QT-prolonging drugs ↑ arrhythmia risk
- arrow_rightSerotonergic drugs may ↑ serotonin syndrome risk (rare)
- arrow_rightApomorphine (contraindicated) → profound hypotension/loss of consciousness
Is Ondansetron a controlled substance?
No. Ondansetron is not a federally controlled substance (it is unscheduled by the DEA).
How to remember Ondansetron (PTCE mnemonic)
ZO-fran aims for ZERO vomiting — onDANSETRON blocks 5-HT3. QT prolongation, headache, constipation; serotonin syndrome with SSRIs.
lightbulb
PTCE exam tip
The suffix -setron = a 5-HT3 antagonist for nausea. Ondansetron (Zofran) often comes as an ODT (orally disintegrating tablet).
Ondansetron FAQ
What is Ondansetron used for?
Ondansetron is used to treat nausea, vomiting. • Prevention of nausea and vomiting associated with chemotherapy and radiation therapy. • Prevention/treatment of postoperative nausea and vomiting.
What drug class is Ondansetron?
Ondansetron is an Antiemetic (5-HT3 antagonist) (Gastrointestinal group).
Is Ondansetron a controlled substance?
No. Ondansetron is not a federally controlled substance (it is unscheduled by the DEA).
Study guides that cover Ondansetron
Free, in-depth guides to the patterns behind this drug — no app needed.
Drug suffix cheat sheetthe suffix that gives away this drug's class
How to memorize the Top 200 drugsa method for locking in brand↔generic pairs
What changed on the 2026 PTCB examthe new domain weights for 2026
How hard is the PTCE?what the pass rate really meansSee all PTCE study guides or browse the full Top 200 drug list.
Drill Ondansetron the way the PTCE asks it
RxReflex turns the Top 200 drugs into fast flashcard rounds, a guided Learn path, pharmacy math, and 40+ cheat sheets. Free to start.
Related drugs in the Gastrointestinal group
Last reviewed August 7, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).