What is the brand name for Linaclotide?
The brand name for Linaclotide is Linzess.
PTCE Top 200 · #178
Linaclotide
Linzess
Linaclotide is the generic name for the brand-name drug Linzess. It is a gc-c agonist (ibs-c/constipation) used to treat IBS-C, chronic constipation. On the PTCE Top 200 drug list, Linaclotide ranks #178 and is one of the most frequently tested gastrointestinal medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Linaclotide |
|---|---|
| Brand name(s) | Linzess |
| Drug class | GC-C agonist (IBS-C/constipation) |
| Class group | Gastrointestinal |
| Common use | IBS-C, chronic constipation |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Linaclotide used for?
Treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (adult; other age indications product-specific).
What drug class is Linaclotide?
Linaclotide is a GC-C agonist (IBS-C/constipation) in the Gastrointestinal group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Linaclotide
- arrow_rightDiarrhea
- arrow_rightAbdominal pain
- arrow_rightGas/flatulence
- arrow_rightBloating
- arrow_rightAbdominal distension
Major interactions
- arrow_rightNo major systemic drug interactions expected (minimal systemic absorption)
- arrow_rightOther laxatives can increase diarrhea/dehydration risk
- arrow_rightDrugs with narrow therapeutic index may have altered absorption if severe diarrhea occurs
Is Linaclotide a controlled substance?
No. Linaclotide is not a federally controlled substance (it is unscheduled by the DEA).
warning Boxed warning
Risk of serious dehydration in pediatric patients less than 2 years of age; contraindicated in <2 years.
How to remember Linaclotide (PTCE mnemonic)
LIN-zess LINes the gut with fluid — linaclotide activates GC-C (IBS-C/CIC). Take EMPTY STOMACH 30 min before breakfast; DIARRHEA is dose-limiting; contraindicated <2yo (boxed); avoid 2 to <6yo.
lightbulb
PTCE exam tip
Linaclotide's boxed warning is pediatric — contraindicated in young children (fatal dehydration risk) — and it's taken on an empty stomach for IBS-C.
Linaclotide FAQ
What is Linaclotide used for?
Linaclotide is used to treat IBS-C, chronic constipation. Treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (adult; other age indications product-specific).
What drug class is Linaclotide?
Linaclotide is a GC-C agonist (IBS-C/constipation) (Gastrointestinal group).
Is Linaclotide a controlled substance?
No. Linaclotide is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Gastrointestinal group
Drill Linaclotide the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).