PTCE Top 200 · #158

Levocetirizine

Xyzal

Levocetirizine is the generic name for the brand-name drug Xyzal. It is an antihistamine (2nd generation) used to treat allergies. On the PTCE Top 200 drug list, Levocetirizine ranks #158 and is one of the most frequently tested respiratory/allergy medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.

Generic nameLevocetirizine
Brand name(s)Xyzal
Drug classAntihistamine (2nd generation)
Class groupRespiratory/Allergy
Common useallergies
DEA scheduleUnscheduled
AvailabilityOver-the-counter (OTC)

What is Levocetirizine used for?

Relief of symptoms associated with seasonal and perennial allergic rhinitis; treatment of chronic idiopathic urticaria (hives).

What drug class is Levocetirizine?

Levocetirizine is an Antihistamine (2nd generation) in the Respiratory/Allergy group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.

Common side effects of Levocetirizine

Major interactions

Is Levocetirizine a controlled substance?

No. Levocetirizine is not a federally controlled substance (it is unscheduled by the DEA).

How to remember Levocetirizine (PTCE mnemonic)

XY-zal = 'eXtra-Zyrtec' — LEVOcetirizine is L-isomer of cetirizine (half-dose, similar effect). Less sedating than Zyrtec but more than loratadine; renal dose-adjust.
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PTCE exam tip

Another isomer play: LEVOcetirizine is the refined isomer of cetirizine — recognize levo-/es-/des- prefixes as 'active version of the parent drug.'

Levocetirizine FAQ

What is the brand name for Levocetirizine?

The brand name for Levocetirizine is Xyzal.

What is Levocetirizine used for?

Levocetirizine is used to treat allergies. Relief of symptoms associated with seasonal and perennial allergic rhinitis; treatment of chronic idiopathic urticaria (hives).

What drug class is Levocetirizine?

Levocetirizine is an Antihistamine (2nd generation) (Respiratory/Allergy group).

Is Levocetirizine a controlled substance?

No. Levocetirizine is not a federally controlled substance (it is unscheduled by the DEA).

Related drugs in the Respiratory/Allergy group

Drill Levocetirizine the way the PTCE asks it

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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).