PTCE Top 200 · #39

Hydroxyzine

Atarax / Vistaril

Hydroxyzine is the generic name for the brand-name drug Atarax. It is an antihistamine (1st generation) used to treat anxiety, itching. On the PTCE Top 200 drug list, Hydroxyzine ranks #39 and is one of the most frequently tested respiratory/allergy medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.

Generic nameHydroxyzine
Brand name(s)Atarax / Vistaril
Drug classAntihistamine (1st generation)
Class groupRespiratory/Allergy
Common useanxiety, itching
DEA scheduleUnscheduled
AvailabilityPrescription only (Rx)

What is Hydroxyzine used for?

Antihistamine with sedative properties used for symptomatic relief of anxiety and for pruritus due to allergic conditions (product‑specific).

What drug class is Hydroxyzine?

Hydroxyzine is an Antihistamine (1st generation) in the Respiratory/Allergy group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.

Common side effects of Hydroxyzine

Major interactions

Is Hydroxyzine a controlled substance?

No. Hydroxyzine is not a federally controlled substance (it is unscheduled by the DEA).

How to remember Hydroxyzine (PTCE mnemonic)

ATA-rax A-Tax-es anxiety — hydrox-YZINE is 1st-gen H1 (sleepy). Anticholinergic: 'hot, dry, red, mad, blind'; QT prolongation in elderly.
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PTCE exam tip

Hydroxyzine is a sedating (1st-generation) antihistamine used for itching and anxiety — note the two brands, Atarax and Vistaril, for the same generic.

Hydroxyzine FAQ

What is the brand name for Hydroxyzine?

The most common brand name for Hydroxyzine is Atarax / Vistaril.

What is Hydroxyzine used for?

Hydroxyzine is used to treat anxiety, itching. Antihistamine with sedative properties used for symptomatic relief of anxiety and for pruritus due to allergic conditions (product‑specific).

What drug class is Hydroxyzine?

Hydroxyzine is an Antihistamine (1st generation) (Respiratory/Allergy group).

Is Hydroxyzine a controlled substance?

No. Hydroxyzine is not a federally controlled substance (it is unscheduled by the DEA).

Related drugs in the Respiratory/Allergy group

Drill Hydroxyzine the way the PTCE asks it

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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).