What is the brand name for Hydrochlorothiazide / Losartan?
The brand name for Hydrochlorothiazide / Losartan is Hyzaar.
PTCE Top 200 · #65
Hydrochlorothiazide / Losartan
Hyzaar
Hydrochlorothiazide / Losartan is the generic name for the brand-name drug Hyzaar. It is an arb + thiazide diuretic used to treat hypertension. On the PTCE Top 200 drug list, Hydrochlorothiazide / Losartan ranks #65 and is one of the most frequently tested cardiovascular medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Hydrochlorothiazide / Losartan |
|---|---|
| Brand name(s) | Hyzaar |
| Drug class | ARB + thiazide diuretic |
| Class group | Cardiovascular |
| Common use | hypertension |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Hydrochlorothiazide / Losartan used for?
• Hypertension: combination therapy to lower blood pressure when multiple agents are needed.
What drug class is Hydrochlorothiazide / Losartan?
Hydrochlorothiazide / Losartan is an ARB + thiazide diuretic in the Cardiovascular group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Hydrochlorothiazide / Losartan
- arrow_rightDizziness
- arrow_rightHypotension
- arrow_rightElectrolyte abnormalities (e.g., low K+/Na+)
- arrow_rightIncreased creatinine
Major interactions
- arrow_rightNSAIDs may reduce antihypertensive effect and ↑ renal dysfunction risk
- arrow_rightLithium: thiazides/ARBs may ↑ lithium levels/toxicity
- arrow_rightPotassium supplements/K-sparing diuretics ↑ hyperkalemia risk (ARB component)
- arrow_rightOther antihypertensives/diuretics ↑ hypotension risk
Is Hydrochlorothiazide / Losartan a controlled substance?
No. Hydrochlorothiazide / Losartan is not a federally controlled substance (it is unscheduled by the DEA).
warning Boxed warning
Fetal toxicity: drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.
How to remember Hydrochlorothiazide / Losartan (PTCE mnemonic)
HY-zaar HItS BP twice — losartan (-SARTAN = ARB) + HCTZ. Watch K+ (ARB↑/HCTZ↓), NO pregnancy, sulfa allergy from HCTZ.
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PTCE exam tip
Hyzaar = losartan (an ARB) + HCTZ (a thiazide). Recognizing both ingredients in a combination antihypertensive is a classic exam skill.
Hydrochlorothiazide / Losartan FAQ
What is Hydrochlorothiazide / Losartan used for?
Hydrochlorothiazide / Losartan is used to treat hypertension. • Hypertension: combination therapy to lower blood pressure when multiple agents are needed.
What drug class is Hydrochlorothiazide / Losartan?
Hydrochlorothiazide / Losartan is an ARB + thiazide diuretic (Cardiovascular group).
Is Hydrochlorothiazide / Losartan a controlled substance?
No. Hydrochlorothiazide / Losartan is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Cardiovascular group
Drill Hydrochlorothiazide / Losartan the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).