What is the brand name for Hydrochlorothiazide / Lisinopril?
The most common brand name for Hydrochlorothiazide / Lisinopril is Zestoretic / Prinzide.
PTCE Top 200 · #58
Hydrochlorothiazide / Lisinopril
Zestoretic / Prinzide
Hydrochlorothiazide / Lisinopril is the generic name for the brand-name drug Zestoretic. It is an ace inhibitor + thiazide diuretic used to treat hypertension. On the PTCE Top 200 drug list, Hydrochlorothiazide / Lisinopril ranks #58 and is one of the most frequently tested cardiovascular medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Hydrochlorothiazide / Lisinopril |
|---|---|
| Brand name(s) | Zestoretic / Prinzide |
| Drug class | ACE inhibitor + thiazide diuretic |
| Class group | Cardiovascular |
| Common use | hypertension |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Hydrochlorothiazide / Lisinopril used for?
• Hypertension: combination therapy to lower blood pressure when multiple agents are needed.
What drug class is Hydrochlorothiazide / Lisinopril?
Hydrochlorothiazide / Lisinopril is an ACE inhibitor + thiazide diuretic in the Cardiovascular group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Hydrochlorothiazide / Lisinopril
- arrow_rightDizziness
- arrow_rightCough
- arrow_rightHypotension
- arrow_rightElectrolyte abnormalities (e.g., low K+/Na+)
- arrow_rightIncreased creatinine
Major interactions
- arrow_rightPotassium supplements/K-sparing diuretics ↑ hyperkalemia risk (ACE inhibitor component)
- arrow_rightNSAIDs may reduce antihypertensive effect and ↑ renal dysfunction risk
- arrow_rightLithium: thiazides/ACE inhibitors may ↑ lithium levels/toxicity
- arrow_rightOther antihypertensives/diuretics ↑ hypotension risk
Is Hydrochlorothiazide / Lisinopril a controlled substance?
No. Hydrochlorothiazide / Lisinopril is not a federally controlled substance (it is unscheduled by the DEA).
warning Boxed warning
Fetal toxicity: drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.
How to remember Hydrochlorothiazide / Lisinopril (PTCE mnemonic)
ZEST-oretic ZESTs BP down — lisinopril (-PRIL = ACE) + HCTZ. Watch cough/angioedema, K+ swings (ACE↑/HCTZ↓), NO pregnancy, sulfa allergy.
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PTCE exam tip
A two-in-one antihypertensive: lisinopril (an ACE inhibitor) + HCTZ (a thiazide). Identifying both ingredients in a combo is a frequent exam item.
Hydrochlorothiazide / Lisinopril FAQ
What is Hydrochlorothiazide / Lisinopril used for?
Hydrochlorothiazide / Lisinopril is used to treat hypertension. • Hypertension: combination therapy to lower blood pressure when multiple agents are needed.
What drug class is Hydrochlorothiazide / Lisinopril?
Hydrochlorothiazide / Lisinopril is an ACE inhibitor + thiazide diuretic (Cardiovascular group).
Is Hydrochlorothiazide / Lisinopril a controlled substance?
No. Hydrochlorothiazide / Lisinopril is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Cardiovascular group
Drill Hydrochlorothiazide / Lisinopril the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).