PTCE Top 200 · #148

Docusate

Colace

Docusate is the generic name for the brand-name drug Colace. It is a stool softener used to treat constipation (softener). On the PTCE Top 200 drug list, Docusate ranks #148 and is one of the most frequently tested gastrointestinal medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.

Generic nameDocusate
Brand name(s)Colace
Drug classStool softener
Class groupGastrointestinal
Common useconstipation (softener)
DEA scheduleUnscheduled
AvailabilityOver-the-counter (OTC)

What is Docusate used for?

Stool softener for prevention/treatment of constipation (facilitates mixing of water/fat into stool).

What drug class is Docusate?

Docusate is a Stool softener in the Gastrointestinal group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.

Common side effects of Docusate

Major interactions

Is Docusate a controlled substance?

No. Docusate is not a federally controlled substance (it is unscheduled by the DEA).

How to remember Docusate (PTCE mnemonic)

COL-ace COAxes stool out — docusate is a surfactant softener (mixes water + fat into stool). GENTLE but SLOW (1-3 days); minimal evidence; works best with hydration/fiber.
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PTCE exam tip

Know the laxative ladder: docusate is a stool SOFTENER for preventing strain — the senna + docusate combo (Senokot-S / Peri-Colace) is the classic pairing with opioid therapy.

Docusate FAQ

What is the brand name for Docusate?

The brand name for Docusate is Colace.

What is Docusate used for?

Docusate is used to treat constipation (softener). Stool softener for prevention/treatment of constipation (facilitates mixing of water/fat into stool).

What drug class is Docusate?

Docusate is a Stool softener (Gastrointestinal group).

Is Docusate a controlled substance?

No. Docusate is not a federally controlled substance (it is unscheduled by the DEA).

Related drugs in the Gastrointestinal group

Drill Docusate the way the PTCE asks it

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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).