What is the brand name for Chlorthalidone?
The most common brand name for Chlorthalidone is Hygroton / Thalitone.
PTCE Top 200 · #124
Chlorthalidone
Hygroton / Thalitone
Chlorthalidone is the generic name for the brand-name drug Hygroton. It is a thiazide-like diuretic used to treat hypertension, edema. On the PTCE Top 200 drug list, Chlorthalidone ranks #124 and is one of the most frequently tested cardiovascular medications — commonly quizzed on its brand–generic pair, drug class, and key side effects.
| Generic name | Chlorthalidone |
|---|---|
| Brand name(s) | Hygroton / Thalitone |
| Drug class | Thiazide-like diuretic |
| Class group | Cardiovascular |
| Common use | hypertension, edema |
| DEA schedule | Unscheduled |
| Availability | Prescription only (Rx) |
What is Chlorthalidone used for?
Treatment of hypertension; management of edema due to heart failure, hepatic cirrhosis, renal dysfunction, or corticosteroid/estrogen therapy.
What drug class is Chlorthalidone?
Chlorthalidone is a Thiazide-like diuretic in the Cardiovascular group. Knowing the class is the fastest way to predict its uses, side effects, and the brand↔generic pairs the PTCE tests.
Common side effects of Chlorthalidone
- arrow_rightHypokalemia
- arrow_rightHyponatremia
- arrow_rightDizziness
- arrow_rightPolyuria
- arrow_rightHyperuricemia (gout)
- arrow_rightHyperglycemia
Major interactions
- arrow_rightLithium → increased lithium levels/toxicity
- arrow_rightDigoxin (esp. with low K/Mg) → arrhythmia risk
- arrow_rightNSAIDs → reduced diuretic/antihypertensive effect, renal risk
- arrow_rightOther antihypertensives → additive hypotension
Is Chlorthalidone a controlled substance?
No. Chlorthalidone is not a federally controlled substance (it is unscheduled by the DEA).
How to remember Chlorthalidone (PTCE mnemonic)
CHLOR-thalidone has CHLORonger action — more potent + longer than HCTZ (T½ ~40hr). ↓K+, ↓Na+, ↑uric acid (gout), photosensitivity; sulfa allergy.
lightbulb
PTCE exam tip
Chlorthalidone is thiazide-LIKE — more potent and much longer-acting than HCTZ, with the same low-potassium watch.
Chlorthalidone FAQ
What is Chlorthalidone used for?
Chlorthalidone is used to treat hypertension, edema. Treatment of hypertension; management of edema due to heart failure, hepatic cirrhosis, renal dysfunction, or corticosteroid/estrogen therapy.
What drug class is Chlorthalidone?
Chlorthalidone is a Thiazide-like diuretic (Cardiovascular group).
Is Chlorthalidone a controlled substance?
No. Chlorthalidone is not a federally controlled substance (it is unscheduled by the DEA).
Related drugs in the Cardiovascular group
Drill Chlorthalidone the way the PTCE asks it
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Last reviewed June 25, 2026. Educational use only — not medical advice. Verify clinical specifics with your pharmacist or a current label source such as DailyMed. RxReflex is not affiliated with or endorsed by the Pharmacy Technician Certification Board (PTCB).