SSRIs
First-line for depression
Depression and anxiety disorders; several also treat OCD, panic disorder and PTSD.
Keeps serotonin available longer in the space between nerve cells by blocking its reuptake.
The 5 ssris in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Sertraline | Zoloft | depression, anxiety |
| Escitalopram | Lexapro | depression, anxiety |
| Fluoxetine | Prozac | depression, OCD, bulimia |
| Citalopram | Celexa | depression |
| Paroxetine | Paxil | depression, anxiety, PTSD |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleUsually the first medication tried for depression.
- check_circleFull benefit typically takes several weeks — patients need to be told this up front.
- check_circleShould be tapered rather than stopped suddenly.
- check_circleSertraline, escitalopram, fluoxetine, paroxetine and citalopram are the ones you'll see most.
Combining serotonin-raising drugs can cause serotonin syndrome — agitation, sweating, tremor and a fast heart rate.
SSRIs come with an antidepressant class warning about suicidal thoughts in younger patients.
Drill ssris the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What drugs are in the ssris class? add
Sertraline, Escitalopram, Fluoxetine, Citalopram, Paroxetine. All are in the PTCB Top 200.
What are ssris used for? add
Depression and anxiety disorders; several also treat OCD, panic disorder and PTSD.
How do ssris work? add
Keeps serotonin available longer in the space between nerve cells by blocking its reuptake.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.