Proton pump inhibitors
Turning acid off
Every generic name in this class ends in -prazole. Heartburn, GERD, stomach ulcers, and protecting the stomach during long-term NSAID use.
Shuts down the stomach's acid pump directly, so far less acid is produced.
The 3 proton pump inhibitors in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Omeprazole | Prilosec | GERD, ulcers |
| Pantoprazole | Protonix | GERD, ulcers |
| Esomeprazole | Nexium | GERD, ulcers |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleEvery generic name ends in -prazole.
- check_circleTaken 30 to 60 minutes before a meal, usually breakfast.
- check_circleDelayed-release capsules and tablets are swallowed whole.
- check_circleLong-term use is linked to lower magnesium and vitamin B12.
Omeprazole reduces the activation of clopidogrel. Pantoprazole is generally preferred when a patient takes both.
-prazole means PPI. H2 blockers such as famotidine are a different, weaker class.
Drill proton pump inhibitors the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What does the suffix -prazole mean? add
A generic drug name ending in -prazole identifies it as one of the proton pump inhibitors. Heartburn, GERD, stomach ulcers, and protecting the stomach during long-term NSAID use.
What drugs are in the proton pump inhibitors class? add
Omeprazole, Pantoprazole, Esomeprazole. All are in the PTCB Top 200.
What are proton pump inhibitors used for? add
Heartburn, GERD, stomach ulcers, and protecting the stomach during long-term NSAID use.
How do proton pump inhibitors work? add
Shuts down the stomach's acid pump directly, so far less acid is produced.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.