Atypical antipsychotics
Beyond schizophrenia
Schizophrenia and bipolar disorder; some are added to an antidepressant for treatment-resistant depression.
Acts on both dopamine and serotonin receptors, which is what makes them 'atypical'.
The 4 atypical antipsychotics in the PTCB Top 200
| Generic | Brand | Common use |
|---|---|---|
| Quetiapine | Seroquel | schizophrenia, bipolar |
| Aripiprazole | Abilify | schizophrenia, bipolar, depression |
| Olanzapine | Zyprexa | schizophrenia, bipolar |
| Risperidone | Risperdal | schizophrenia, bipolar, autism |
Tap any generic name for its full drug guide — brand↔generic, side effects, interactions and the exam tip.
What to know for the exam
- check_circleWeight gain, high blood sugar and abnormal cholesterol are monitored throughout treatment.
- check_circleSeveral are available as long-acting injections given in the clinic.
- check_circleQuetiapine is often prescribed at low doses for sleep.
- check_circleMovement side effects are less common than with the older antipsychotics but still occur.
Boxed warning: increased risk of death when used for dementia-related psychosis in elderly patients.
Metabolic monitoring — weight, glucose, lipids — is the routine tied to this class.
Drill atypical antipsychotics the way the PTCE asks them
RxReflex groups the Top 200 drugs into classes like this one, then quizzes you on brand↔generic, class, side effects and interactions. Plus a guided Learn path, pharmacy math and 40+ cheat sheets. Free to start.
Frequently asked
What drugs are in the atypical antipsychotics class? add
Quetiapine, Aripiprazole, Olanzapine, Risperidone. All are in the PTCB Top 200.
What are atypical antipsychotics used for? add
Schizophrenia and bipolar disorder; some are added to an antidepressant for treatment-resistant depression.
How do atypical antipsychotics work? add
Acts on both dopamine and serotonin receptors, which is what makes them 'atypical'.
Last reviewed August 7, 2026. For education only — not medical advice. Not affiliated with or endorsed by the PTCB.